This one-hour, journal article–based activity details the emergence of medetomidine, a potent veterinary α2-adrenergic agonist, as a dangerous adulterant in the illicit fentanyl supply. The article characterizes a novel, severe withdrawal syndrome that is distinct from standard opioid withdrawal, often requiring intensive care and aggressive α2-agonist therapies. This review is important for clinicians to recognize and manage this high-acuity syndrome as it spreads beyond initial geographic hotspots.

This one-hour, journal article–based activity explores key clinical predictors of treatment success for methamphetamine use disorder (MUD) by analyzing secondary data from the landmark ADAPT-2 trial. The article examines how patient levels of craving and impulsivity correlate with transitions between positive and negative urine drug screens (UDS) in individuals receiving a combination of injectable naltrexone and oral bupropion. These findings provide insights for clinicians aiming to optimize pharmacotherapy outcomes and tailor interventions for a high-risk population currently lacking FDA-approved medication options.

This one-hour, journal article–based activity examines the lack of standardized terminology for individuals with substance use disorders who do not achieve remission despite multiple treatment attempts. The scoping review evaluates how terms like "treatment-refractory" and "treatment-resistant" are defined in the literature, identifying significant variability in how clinicians and researchers categorize this high-risk population. By establishing a foundation for a consensus definition, this review informs the development of person-first language and tailored clinical interventions for patients with complex, persistent treatment needs.

This one-hour, on-demand, journal article–based activity examines interventions designed to maintain smoking abstinence in postpartum individuals who quit smoking during pregnancy. The systematic review and network meta-analysis compare cognitive behavioral therapy (CBT), motivational interviewing (MI), and combined CBT-MI approaches, assessing their effectiveness at maintaining abstinence at 6 and 12 months postpartum. The article highlights challenges in sustaining long-term abstinence, identifies factors associated with postpartum relapse, and evaluates the current evidence base for psychosocial interventions aimed at reducing postpartum smoking relapse. This review provides insights for clinicians and public health professionals seeking to support ongoing abstinence and improve maternal and child health outcomes during the postpartum period.

This one-hour, on-demand, journal article–based activity examines youth-specific overdose prevention interventions, an important topic given the rising overdose deaths among adolescents and young adults. The article reviews existing educational programs designed to improve overdose awareness, risk recognition, and response among youth. It highlights features of current programs, describes how interventions have been evaluated, and identifies gaps in the evidence on effectiveness, implementation, and distribution. This review provides context for understanding the current conditions of youth overdose prevention efforts and informs future public health and clinical education strategies.

This one-hour, on-demand, journal article-based activity examines how demographic and contextual factors may influence ASAM level of care recommendations for individuals with substance use disorders. Understanding potential biases and disparities in treatment placement is important to ensure equitable and effective care. This article helps learners recognize factors that may influence ASAM ratings, interpret assessment results thoughtfully, and consider strategies to support fair and evidence-informed placement decisions.

This one-hour, on-demand, journal article-based activity examines patterns of non-medical mephentermine use, associated psychiatric and physical complications, and current treatment approaches. It equips clinicians to recognize high-risk populations, identify potential complications, and apply evidence-informed strategies for clinical assessment, intervention, and patient education.

This one-hour, on-demand, journal article-based activity explores the experiences of people with opioid use disorder who become pregnant, focusing on how pregnancy options counseling was provided, perceived, and influenced by healthcare interactions. This article offers insights into patient perspectives, highlights barriers such as stigma and bias, and suggests strategies for providing patient-centered, nonjudgmental pregnancy counseling.

This one-hour, on-demand, journal article-based activity examines how Medicaid unwinding (the resumption of normal Medicaid eligibility checks) affected buprenorphine treatment for opioid use disorder (OUD). This study assesses changes in both new and ending treatment episodes following Medicaid disenrollment.

This one-hour, on-demand, journal article-based activity examines the impact of stimulant use disorders (StSUD) on major cardiovascular complications, highlighting differences in cardiovascular risk compared with other substance use disorders.

This one-hour, on-demand, journal article-based activity examines how the Consultation for Addiction Care and Treatment in Hospitals (CATCH) program impacts the delivery of medications for opioid use disorder (MOUD) during hospitalization across six New York City public hospitals.

This one-hour, on-demand, journal article-based activity explores the use of buprenorphine to treat opioid use disorder while considering risks and potential disengagement. This article focuses on the transition to extended-release or long-acting buprenorphine to improve outcomes and treatment adherence.

This one-hour, on-demand, journal article-based activity examines the relationship between methadone dosing during the first week of treatment and 30-day treatment retention. This article addresses early dropout challenges and offers solutions to patients' adherence to treatment.

This one-hour, on-demand, journal article-based activity examines the prevalence of continued substance use in the United States among adults who self-identified as being in recovery, including demographic and psychosocial factors. Since many adults in recovery continue to use substances, such as alcohol and cannabis, treatment and recovery services may enhance participation and effectiveness by accommodating goals that do not require complete abstinence.

This one-hour, on-demand, journal article-based activity reviews findings from a systematic review and meta-analysis on the effectiveness and safety of naltrexone as a standalone pharmacotherapy for amphetamine-type stimulant use disorder (ATSUD). Drawing from five randomized controlled trials, the article examines naltrexone’s impact on stimulant use, study retention, craving, and adverse effects.