This one-hour, journal article–based activity details the emergence of medetomidine, a potent veterinary α2-adrenergic agonist, as a dangerous adulterant in the illicit fentanyl supply. The article characterizes a novel, severe withdrawal syndrome that is distinct from standard opioid withdrawal, often requiring intensive care and aggressive α2-agonist therapies. This review is important for clinicians to recognize and manage this high-acuity syndrome as it spreads beyond initial geographic hotspots.

This one-hour, journal article–based activity explores key clinical predictors of treatment success for methamphetamine use disorder (MUD) by analyzing secondary data from the landmark ADAPT-2 trial. The article examines how patient levels of craving and impulsivity correlate with transitions between positive and negative urine drug screens (UDS) in individuals receiving a combination of injectable naltrexone and oral bupropion. These findings provide insights for clinicians aiming to optimize pharmacotherapy outcomes and tailor interventions for a high-risk population currently lacking FDA-approved medication options.

This one-hour, journal article–based activity examines the lack of standardized terminology for individuals with substance use disorders who do not achieve remission despite multiple treatment attempts. The scoping review evaluates how terms like "treatment-refractory" and "treatment-resistant" are defined in the literature, identifying significant variability in how clinicians and researchers categorize this high-risk population. By establishing a foundation for a consensus definition, this review informs the development of person-first language and tailored clinical interventions for patients with complex, persistent treatment needs.

This one-hour, on-demand, journal article–based activity examines interventions designed to maintain smoking abstinence in postpartum individuals who quit smoking during pregnancy. The systematic review and network meta-analysis compare cognitive behavioral therapy (CBT), motivational interviewing (MI), and combined CBT-MI approaches, assessing their effectiveness at maintaining abstinence at 6 and 12 months postpartum. The article highlights challenges in sustaining long-term abstinence, identifies factors associated with postpartum relapse, and evaluates the current evidence base for psychosocial interventions aimed at reducing postpartum smoking relapse. This review provides insights for clinicians and public health professionals seeking to support ongoing abstinence and improve maternal and child health outcomes during the postpartum period.

This one-hour, on-demand, journal article–based activity examines youth-specific overdose prevention interventions, an important topic given the rising overdose deaths among adolescents and young adults. The article reviews existing educational programs designed to improve overdose awareness, risk recognition, and response among youth. It highlights features of current programs, describes how interventions have been evaluated, and identifies gaps in the evidence on effectiveness, implementation, and distribution. This review provides context for understanding the current conditions of youth overdose prevention efforts and informs future public health and clinical education strategies.