This one-hour, journal article-based activity examines associations between social-environmental vulnerability (SEV), healthcare service presence, and opioid overdose rate acceleration across rural and urban communities in the United States. Learners will explore how vulnerability and geographic context are associated with differences in overdose trends and examine the relationship between the presence of opioid treatment programs (OTPs) and primary care providers (PCPs) services and overdose rate acceleration. The article also considers how healthcare service presence in high-vulnerability communities may inform strategies to address geographic and social disparities in opioid overdose outcomes.

This one-hour, journal article-based activity examines the efficacy and safety of methylphenidate (MPH) for the treatment of cocaine use disorder (CUD). Learners will explore findings from a systematic review and meta-analysis evaluating the effects of MPH on cocaine craving and use, including differences in outcomes among individuals with and without co-occurring attention-deficit/hyperactivity disorder (ADHD). The article also examines factors that may influence treatment outcomes, considerations related to the safety of MPH, and limitations in the current evidence base to inform future research and clinical practice.

This one-hour, journal article-based activity examines the efficacy and safety of pharmacological interventions for electronic cigarette cessation. Learners will explore current evidence for varenicline, nicotine replacement therapy (NRT), and cytisine, including their effects on abstinence and reported adverse events. The article also examines current limitations in the evidence base and considerations for applying pharmacological approaches to support adults seeking to stop using electronic cigarettes.

This one-hour, journal article-based activity examines ongoing clinical trials for cocaine use disorder (CUD) and evaluates how well ongoing studies align with recent Food and Drug Administration (FDA) recommendations. Learners will explore trends in trial design, including the use of pharmacologic, behavioral, device-based, and digital interventions, while examining common strengths and gaps in current research. The activity also discusses how adherence to regulatory guidance may influence the development, evaluation, and future implementation of effective treatments for CUD.

This one-hour, journal article-based activity examines differences in medication for opioid use disorder (MOUD) implementation between primary care clinics and specialty addiction treatment programs. Learners will explore how organizational capacity, workforce characteristics, implementation climate, and community-level factors influence the adoption and delivery of MOUD across treatment settings. The article also examines opportunities to tailor implementation strategies to address setting-specific barriers, improve access to evidence-based treatment, and support equitable expansion of MOUD services for individuals with opioid use disorder.