Naloxone, Nalmefene, and Naltrexone: Is There a Need for Three Opioid Antagonists?

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Logo for ASAM's 55th Annual Conference

Naloxone, Nalmefene, and Naltrexone: Is There a Need for Three Opioid Antagonists?
Developed in Collaboration with the American College of Medical Toxicology

Recorded: Thursday, April 4, 2024 to Sunday, April 7, 2024
On-Demand Session

Overview

This 75-minute on-demand session from the ASAM 55th Annual Conference addresses the clinical risk and benefit of the various opioid reversal agents in the management of patients following an opioid overdose with special attention to patients using fentanyl and nitazenes.

An improved understanding of the clinical pharmacology of naloxone, nalmefene, and related agents will provide attendees with the tools to choose among various opioid antagonist products and formulations and provide targeted, efficient, safe overdose management to patients with acute opioid overdose or precipitated opioid withdrawal.

The target audience for this Intermediate level session includes physicians, nurse practitioners, physician assistants, other clinicians, researchers, residents, fellows, students, and counselors.

This session addresses the following ACGME Competencies: Patient Care and Procedural Skills

This session addresses the following ICPE Competencies:Roles and Responsibilities

Learning Objectives

Upon completion, learners will be able to:

  1. Describe the pharmacology of naloxone, nalmefene, naltrexone, and buprenorphine including their pharmacokinetic profiles
  2. Discuss the clinical risk and benefit of the various opioid reversal agents in the management of patients following an opioid overdose with special attention to patients using fentanyl and nitazenes.
  3. Explain the risk and treatment of precipitated withdrawal in the acute care setting, including the use of buprenorphine.

Registration Rates

Rate DescriptionRate
ASAM Member$29
Non-Member$39
Associate Member$19
Resident Member*$19
Student Member*$19

*Residents, Fellows-in-training, Interns, and Students must join ASAM to receive a discounted registration rate. Click here to become an ASAM member. National and Chapter membership dues apply. There is no charge for Students to become a Member, but verification of student status is required.

Membership Question?  Call ASAM at 1.301.656.3920, email us, or view the ASAM website for more information.

Refunds & Cancellations

All ASAM eLearning Center refund requests must be made in writing to education@asam.org within 90 days of purchase. Those requesting refunds for courses that are in progress will receive partial refunds or e-Learning Center credit. Automatic full refunds will be made for any course with a live-course component that has been cancelled.

Registration Open: 05/06/2024 - 04/06/2027

User Access Closed: 05/06/2027

Session Instructions

  1. Click on the Contents tab to watch the on-demand recording.
  2. Click Complete Post Test to answer multiple choice questions. Participants will have 10 attempts to pass and must answer 4 out of 5 questions correctly.
  3. Click Complete Evaluation to provide valuable activity feedback. Scroll down on all questions as there may be answer options that expand past the size of the window.
  4. Click the button Claim Medical Credits in the box titled Claim Credits & Certificate. Choose the type of credit and click submit. Click the button View/Print Certificate to save or print your certificate. You can view/print your certificate at any time by visiting the ASAM eLearning Center, clicking Dashboard, and clicking Transcript/Achievements.

Need Assistance?

For assistance logging in, accessing activities, claiming credit, or for other questions or concerns, please check the FAQ page or e-mail Education@ASAM.org

ASAM is proud to offer Essential Accessibility to ensure our website is accessible and functional for all our learners while providing free assistive technology for people with the widest possible range of abilities.

Lewis S. Nelson

MD

Dr. Nelson is Professor and Chair of the Department of Emergency Medicine and Chief of the Division of Medical Toxicology at Rutgers New Jersey Medical School in Newark, NJ. He is a member of the Board of Directors of the American Board of Emergency Medicine and a Past-President of the American College of Medical Toxicology. He remains actively involved with CDC, FDA, DHS, and with several professional medical organizations including ASAM. Dr. Nelson is an editor of the textbook Goldfrank’s Toxicologic Emergencies and on the editorial boards of several journals. In addition to providing direct clinical care to patient in the ED and his efforts at New Jersey Poison Information & Education System, his specific expertise include the consequences of licit and illicit opioids, emerging drugs of abuse, opioid stewardship, and alcohol withdrawal.

Evan S. Schwarz

MD

Dr. Evan Schwarz is an Associate Professor of Emergency Medicine and the Medical Toxicology Section Chief at the Washington University School of Medicine. Additionally, he is board certified in Addiction Medicine. He directs the medical toxicology and addiction medicine consultation service as well as their outpatient clinic and organized the Emergency Department buprenorphine treatment program. In addition to his work responsibilites, he is a member of the board of directors for the American College of Medical Toxicology and the President of the Missouri College of Emergency Physicians. He was appointed to the Opioid Advisory Committee through Missouri HealthNet and the Department of Social Services and is a physician consultant for Missouri’s State Targeted Response. 

JoAn Leas

MD

JoAn Laes, MD is an addiction medicine physician at Hennepin Healthcare in Minneapolis, Minnesota, focusing on inpatient addiction medicine and toxicology consultation as well as outpatient treatment of opioid and other substance use disorders. She is a core medical toxicology faculty for the Minnesota Poison Center, Minneapolis, Minnesota, medical director for Missions Inc. Detox facility in Plymouth, Minnesota and 1800 Chicago detox facility in Minneapolis, MN and a nocturnist at Mercy Hospital in Coon Rapids, Minnesota. She is the chair of the medical toxicology workgroup for the American Society of Addiction Medicine and the president elect for the Minnesota chapter of ASAM. She completed internal medicine residency at Hennepin County Medical Center and medical toxicology fellowship at Regions Hospital in St. Paul, Minnesota and is board certified in Internal Medicine, Medical Toxicology, and Addiction Medicine.

Accreditation & Credit Designation Statements

Joint Accreditation Statement
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In support of improving patient care, the American Society of Addiction Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians

The American Society of Addiction Medicine designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses

This activity awards 1.25 Nursing contact hours.

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PAs

ASAM has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.25 AAPA Category 1 CME credits. Approval is valid until 05/06/2027.  PAs should only claim credit commensurate with the extent of their participation.

Social Workers

As a Jointly Accredited Organization, ASAM is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. Regulatory boards are the final authority on courses accepted for continuing education credit. Social workers completing this course receive 1.25 general continuing education credits.

IPCE Credit

This activity was planned by and for the healthcare team, and learners will receive 1.25 Interprofessional Continuing Education (IPCE) credits for learning and change.

California Association for Drug/Alcohol Educators (CAADE)

This educational program is approved by CAADE: #CP40 999 1225.

California Association of DUI Treatment Centers (CADTP)

This educational program is approved by CADTP: #205.

California Consortium of Addiction Programs and Professionals (CCAPP)

This educational program is approved by CCAPP: #OS-20-330-1224.

Continuing Education Credits (CEUs)

Upon completion of the activity and online evaluation, all other participants may request a certificate of participation. Participants may submit this certificate of participation to their professional organization/institute as documentation for completing this accredited continuing activity.

Maintenance of Certification (MOC) or Continuing Certification Programs (CCP)

This activity meets the requirements for MOC/CCP for the following primary physician boards and for state licensing CME requirements. MOC Credit is only reported for ABA, ABP, ABIM, and ABS. By completing the online credit application and evaluation, the learner permits ASAM to report credits to the appropriate Board. Learn more.

  • American Board of Medical Specialties (ABMS)
  • American Board of Preventive Medicine (ABPM)
  • American Board of Internal Medicine (ABIM)
  • American Board of Pediatrics (ABP)
  • American Board of Surgery (ABS)
  • American Board of Psychiatry and Neurology (ABPN)
  • American Board of Addiction Medicine (ABAM)
  • Royal College of Physicians and Surgeons of Canada (RCPSC)
    • Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons in Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Disclosure Information

In accordance with disclosure policies of ASAM and Joint Accreditation, the effort is made to ensure balance, independence, objectivity, and scientific rigor in all CME/CE activities. These policies include mitigating all relevant financial relationships with ineligible companies for the Planning Committees and Presenters. All activity Planning Committee members and Presenters have disclosed all financial relationship information. The ASAM CE Committee has reviewed these disclosures and determined that the relationships are not inappropriate in the context of their respective presentations and are not inconsistent with the educational goals and integrity of the activity. Click here to view the full disclosure listing.

Key:

Complete
Failed
Available
Locked
View On-Demand Recording
Open to view video.
Open to view video. Video is approximately 75 minutes long. Recorded between 04/04/24 - 04/07/24.
Complete Post Test
5 Questions  |  10 attempts  |  4/5 points to pass
5 Questions  |  10 attempts  |  4/5 points to pass This post-test has 5 questions and requires 4 out of 5 to pass the quiz.
Complete Evaluation
15 Questions
15 Questions Scroll down on evaluation, there may be questions that expand past the size of the window.
Claim Credit & Certificate
Up to 1.25 medical credits available  |  Certificate available
Up to 1.25 medical credits available  |  Certificate available Attendees should claim only the credit commensurate with the extent of their participation in the activity.