Novel Benzodiazepines and Sedative-Hypnotics: Down but Not Out

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ASAM Virtual 2021

Novel Benzodiazepines and Sedative-Hypnotics: Down but Not Out

Recorded: Thursday, April 22, 2021 - Saturday, April 24, 2021
On-Demand Session

Overview

This 1.5-hour on-demand session from ASAM Virtual 2021 addresses the variety of novel benzodiazepines and the often little known knowledge about half life, onset effects, and other drug interactions and also their difficulty in laboratory detection.

The variety and number of “novel” benzodiazepines (e.g., etizolam, flubromazolam, clobazolam) and sedative-hypnotics (e.g., phenibut and gamma-hydroxybutyrate analogues [GHB] analogues including 1,4-butanediol) continue to increase in the United States. Difficulty exists in elucidating the pharmacokinetics and laboratory detection of these newer substances- there is often little known about half life, onset of effects, and other drug interactions- and medical providers are faced with difficult decisions for withdrawal management and tapering or “detoxing” patients. To illustrate the complexity of novel sedative-hypnotic misuse and management of use disorders and withdrawal, several cases will be discussed highlighting many of the newer benzodiazepines, phenibut, and GHB analogues. The session will include a didactic portion to describe the epidemiology, availability, and known pharmacology of these agents.

The target audience for this intermediate level session includes physicians, nurse practitioners, physician assistants, other clinicians, researchers, residents, fellows, students, and counselors.

This session addresses the following ACGME Competencies: Patient Care, Medical Knowledge, Practice-Based Improvement, Systems Based Practice.

Learning Objectives

Upon completion, learners will be able to:

  1. Discuss the current market of “novel” benzodiazepines and sedative-hypnotics such as phenibut and gamma-hydroxybutyrate analogues, including availability, use patterns, pharmacology, and methods of detection
  2. Explain the pathophysiology and clinical presentation of withdrawal from novel sedative-hypnotics and whether this differs from traditional benzodiazepine withdrawal
  3. Discuss the management of use disorders and withdrawal syndromes of novel sedative-hypnotics using GABA agonists and non-GABA agonists in a variety of medical settings

Fees

Rate DescriptionRate
ASAM Member$29
Non-Member$39
Associate Member$19
Resident Member*$19
Student Member*$19

*Residents, Fellows-in-training, Interns, and Students must join ASAM to receive a discounted registration rate. Click here to become an ASAM member. National and Chapter membership dues apply. There is no charge for Students to become a Member, but verification of student status is required.

Membership Question?  Call ASAM at 1.301.656.3920, email us, or view the ASAM website for more information.

Refunds & Cancellations

All ASAM e-Learning Center refund requests must be made in writing to education@asam.org within 90 days of purchase. Those requesting refunds for courses that are in progress will receive partial refunds or e-Learning Center credit. Automatic full refunds will be made for any course with a live-course component that has been cancelled.

Registration Deadline: 04/30/2024

Course Instructions

  1. Click the "Contents" tab and select "View Introductory Video".  After viewing the entire video, return to the Contents tab.
  2. Select "View On-Demand Recording".  After viewing the entire video, return to the Contents tab.
  3. Click "Complete Post Test" to answer quiz questions. You will have 10 attempts and must get at least 4 out of 5 questions correct. After completing the quiz, return to the Contents tab. 
  4. Click "Complete Evaluation" to answer evaluation questions. Scroll down on all questions, there are answers that expand past the size of the window. 
  5. Click the button “Claim Credits” in the box titled “Claim Credits & Certificate." Choose the type of credit and click submit. Click the button “View/Print Certificate” to save or print your certificate. If you ever lose your certificate, you can come back to the ASAM e-Learning Center and view it on your transcript (found in the Dashboard).

Need Assistance?

If you have are experiencing any log in issues, cannot access a course, need assistance claiming credit, or have other questions or concerns, please e-mail Education@asam.org for assistance.

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JoAn Laes

MD

JoAn Laes, MD is an addiction medicine physician and consulting medical toxicologist. Her focus is inpatient addiction medicine and toxicology consultation, and outpatient treatment of opioid and other substance use disorders. She is an owner at Twin Cities Toxicology, providing consultation, medical directorship, and expert opinion in the fields of addiction medicine and medical toxicology. She is board-certified in Internal Medicine, Addiction Medicine, and Medical Toxicology. She completed an internal medicine residency at Hennepin County Medical Center and medical toxicology fellowship at Regions Hospital in St. Paul, Minnesota. She has spoken nationally on the subjects of addiction medicine and toxicology.

Timothy Wiegand

MD, FACMT, FAACT, DFASAM

Timothy Wiegand, MD, FACMT, FAACT, DFASAM is the Director of Toxicology for the University of Rochester Medical Center and an Associate Professor of Emergency Medicine with secondary appointment in Public Health Sciences. He holds Board Certification in Medical Toxicology and Addiction Medicine and has an active clinical practice through the Department of Emergency Medicine running the Toxicology Consult Service, which serves as the foundation for the toxicology/addiction rotation at URMC. Dr Wiegand is also the Associate Fellowship Director for the URMC Combined Addiction Medicine Fellowship and he serves as Medical Director for Huther Doyle a Rochester, NY area outpatient addiction treatment program. Dr. Wiegand is active professionally with a variety and he serves on the Board of Directors for the American College of Medical Toxicology, the American Society of Addiction Medicine Board as an At-Large Director and is President Elect of the New York Society of Addiction Medicine. Dr. Wiegand also serves on the Board of the Medical Toxicology Foundation which has as a priority to support research, innovation and education related to the interface of toxicology and addiction in particular related to the opioid and overdose epidemic. 

Dr. Wiegand lectures on a variety of toxicology and addiction subjects at state and national events as well as internationally including the treatment of drug and alcohol withdrawal, on the use of buprenorphine to stabilize opioid withdrawal in Emergency Department and hospital settings, and on the treatment of pain and perioperative management for patients on buprenorphine and methadone. 

Jeremiah D. Fairbanks

DO

Jeremiah Fairbanks, DO is a current addiction medicine fellow at the University of Minnesota. He completed his medical training at Des Moines University followed by a family medicine residency through the University of Minnesota. He has helped develop programs treating office based opioid use disorder through primary care in southern Minnesota and has his family medicine board certification. 

CME, CE, CEU and Other Credit Types

ACCME Accredited with Commendation

ACCME Accreditation Statement
The American Society of Addiction Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA Credit Designation Statement
The American Society of Addiction Medicine designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Academy of Physician Assistants
This activity has been reviewed by the AAPA Review Panel and is compliant with AAPA CME Criteria. This activity is designated for 1.5 AAPA Category 1 CME credits. Approval is valid from 5/26/2021 to 5/26/2022. PAs should only claim credit commensurate with the extent of their participation. AAPA reference number: CME-202755.

NAADAC, the Association for Addiction Professionals
This activity has been approved by the American Society of Addiction Medicine, as a NAADAC Approved Education Provider, for educational credits. NAADAC Provider #295, ASAM is responsible for all aspects of the programming.

California Association for Drug/Alcohol Educators (CAADE)
This educational program is approved by CAADE: #CP40 999 1222.

California Association of DUI Treatment Centers (CADTP)
This educational program is approved by CADTP: #205.

California Consortium of Addiction Programs and Professionals (CCAPP)
This educational program is approved by CCAPP: #OS-20-330-1222.

Continuing Education Credits (CEUs)
Non-physician participants will receive a certificate of attendance upon completion of the activity and an online evaluation confirming their participation. Participants should submit his/her certificate of attendance to their professional organization/institute.

Maintenance of Certification (MOC) or Continuing Certification Programs (CCP)

American Board of Medical Specialties (ABMS)
Through the American Board of Medical Specialties (“ABMS”) ongoing commitment to increase access to practice relevant Continuing Certification Activities through the ABMS Continuing Certification Directory, The ASAM Virtual.2021 has met the requirements as a MOC Part II CME Activity (apply toward general CME requirement) for the following ABMS Member Boards: Allergy and Immunology, Anesthesiology, Colon and Rectal Surgery, Family Medicine, Medical Genetics and Genomics, Nuclear Medicine, Physical Medicine and Rehabilitation, Plastic Surgery, Preventive Medicine, Psychiatry and Neurology, Radiology, Thoracic Surgery, Urology

American Board of Preventive Medicine (ABPM)
The American Board of Preventive Medicine (ABPM) has approved this activity for a maximum of 1.5 credit towards ABPM MOC Part II requirements.

American Board of Anesthesiology (ABA)
This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in Anesthesiology TM (MOCA®) program, known as MOCA 2.0®.

American Board of Pediatrics (ABP)
Successful completion of this CME activity, which includes participation in the activity, with individual assessments of the participant and feedback to the participant, enables the participant to earn a maximum of 1.5 MOC point in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Internal Medicine (ABIM)
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 Medical Knowledge MOC point in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credits.

American Board of Surgery (ABS)
Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and/or Self-Assessment requirements of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

American Board of Psychiatry and Neurology (ABPN)
Successful completion of this CME activity can be used to satisfy the American Board of Psychiatry and Neurology’s (ABPN) CME requirement for Maintenance of Certification program. 

American Board of Addiction Medicine (ABAM)
Successful completion of this activity can be used to satisfy the American Board of Addiction Medicine (ABAM) Tmoc credit requirements.

Royal College of Physicians and Surgeons of Canada (RCPSC)
Royal College Fellows can use participation in Accredited Continuing Medical Education to earn Section 3 Credits.

CME Committee, Program Planning Committee, and Faculty Disclosure Information

In accordance with disclosure policies of ASAM and the ACCME, the effort is made to ensure balance, independence, objectivity, and scientific rigor in all CME activities. These policies include mitigating all possible relevant financial relationships with ineligible companies for the Planning Committees, CME Committee, MEC, and Faculty. All activity Planning Committee members and Faculty have disclosed relevant financial relationship information. The ASAM CME Committee has reviewed these disclosures and determined that the relationships are not inappropriate in the context of their respective presentations and are not inconsistent with the educational goals and integrity of the activity.

To view all disclosures click here. 

Key:

Complete
Failed
Available
Locked
View Introductory Video
Open to view video.
Open to view video. This activity should take 30 minutes to complete. Revised April 2021
View On-Demand Recording
Open to view video.
Open to view video. Video is approximately 60 minutes long. Recorded on 4/22/2021.
Complete Post Test
5 Questions  |  10 attempts  |  4/5 points to pass
5 Questions  |  10 attempts  |  4/5 points to pass This post test has 5 questions and requires 4 out of 5 to pass the test.
Complete Evaluation
15 Questions
15 Questions Scroll down on evaluation, there may be questions that expand past the size of the window.
Claim Credits & Certificate
Up to 1.50 medical credits available  |  Certificate available
Up to 1.50 medical credits available  |  Certificate available Attendees should claim only the credit commensurate with the extent of their participation in the activity.